Synext is a scientifically supported supplement that provides the body with essential nutrients, addressing age-related health concerns and supporting improved heart function while strengthening bone health and boosting your sense of wellness.

One of the key nutrients in Synext is Niacin (Vitamin B3), which offers profound benefits in supporting brain health and cognitive function. However, Niacin is also known for causing a phenomenon called the “Niacin flush”, where the skin in the face, neck and chest becomes red, or flushed, accompanied by a tingling sensation. This is a completely harmless effect, but many do wonder why it occurs.

In fact, the niacin flush is a sign that the nutrient is doing its job, but to explain why, let us explore the science behind this phenomenon and its connection to neurological benefits.

Niacin Flush: A Sign of Action, Not Concern

Researchers found that the receptor for Niacin, that is the cells that react to its presence, causes several effects when activated. That receptor is called GPR109A, and while it has several effects, the most prominent is the suppression of pro-inflammatory signalling proteins called cytokines. One of the consequences of fewer of these cytokines is that the body is better able to optimise cholesterol levels and an increase in anti-inflammatory effects.

But there is another, activation of GPR109A also causes vasodilation, which is the relaxation of the blood vessel walls, widening the tube and allowing more blood to flow through. This is the cause of the niacin flush and is in fact a benefit. When the blood vessel widens, blood pressure lowers, adding another benefit to the many reasons why Synext is one of the best supplements for overall wellness you will find.

How Niacin Protects Brain Functionality

The root of the niacin flush comes from how it protects the brain, and the best way to show that is to look at how Niacin works when used to treat Parkinson’s disease. A 2015 study into the effects of niacin on Parkinson’s patients after 45 days of niacin supplementation. Key outcomes included:

• 50% enhancement in quality of life.
• Improved motor function and sleep patterns (REM and deep sleep).
• Reduced neuroinflammation, attributed to GPR109A-mediated cytokine suppression.

These findings suggest that niacin’s activation of GPR109A not only drives the flush reaction but also supports brain health by mitigating inflammation.

Conclusion

In conclusion, the niacin flush reflects the body’s vascular and anti-inflammatory response to niacin’s activation of the GPR109A receptor. While not everyone experiences this reaction, it is generally harmless and may indicate that the supplement is actively supporting circulatory and neurological health.

For Sensitive Users: If the flush feels uncomfortable, consider taking Synext after meals or reducing the dosage to half a tablet at a time.

By understanding this mechanism, you can confidently incorporate Synext into your wellness routine, knowing its effects are both evidence-based and beneficial.