Are There Possible Side Effects?

When taking Synext, especially on an empty stomach, some users may experience an itchy, tingling, or hot feeling accompanied by red flushes on the skin (flushing). This is a normal and harmless reaction, also called “Niacin flush” and it is beneficial to the skin. This should not be mistaken as an allergic reaction.

Any flushing or irritation will dissipate naturally after 5 to 20 minutes. Drinking water will help to reduce the effects of flushing or irritation faster.

To reduce instances of side effects we recommend taking Synext with or immediately after meals.

Your body’s tolerance for the effects of Synext will increase over time. After the period of conditioning, instances of flushing or irritation should reduce substantially.

What is Niacin Flush?

The “flushing” effect corresponds to the vasodilation response of your blood capillaries. This leads to increased blood flow to your skin cells, resulting in a sensation of warmth and redness. This physiological reaction serves to nourish your skin cells and eliminate metabolic waste. Importantly, this phenomenon is not indicative of an allergic reaction (for instance, antihistamine tablets do not impede these effects) and poses no harm to your overall well-being.

The intensity of the “flushing” effect is linked to the inflammation levels within your body and will progressively diminish as your inflammation levels decrease.

Harvard Medical School More on niacin: No flush, no good

Recommended Precautions

Not recommended for use by pregnant and breastfeeding women.

Not suitable for children.

Do NOT take this product if:

  • You are allergic to any of the ingredients in this product.
  • You have severe liver disease.
  • You have stomach ulcers.
  • You are undergoing chemotherapy or radiotherapy treatment.
  • You are undergoing warfarin therapy, without medical advice.

If you are taking any regular medications or undergoing any treatment for chronic or acute conditions seek advice from your treating physician prior to taking Synext.

Difference Between Synext and Synext Lite

Synext focuses on rapidly boosting the nutrient for starters. Synext Lite is appropriate for maintaining nutrient levels in a healthy range. Synext Lite maintains NAD+ recycling and can be taken by those who already have healthy NAD+ levels.

What are Cellular Senescence and Senolytics?

Senescent cells are the result of healthy cells undergoing a process known as cell senescence when they become damaged. These senescent cells typically lose their functionality and the ability to grow or divide. Additionally, they release inflammatory mediators called SASP (senescence-associated secretory phenotype), which serve to attract the immune system for their removal. However, as individuals age, the immune system tends to weaken, making it less effective at clearing senescent cells. Consequently, these “zombie cells” accumulate in various tissues and organs, contributing to the development of numerous chronic diseases. These conditions include diabetes, cardiovascular diseases, cancer, Alzheimer’s disease, cataracts, osteoporosis, and COPD (chronic obstructive pulmonary disease).

Senolytics and senotherapy are approaches aimed at either eliminating senescent cells or mitigating the detrimental effects of the inflammatory mediators (SASP) released by these cells. Senolytics are medications designed to aid in the removal of senescent cells. These drugs have demonstrated the ability to prolong the lifespan of mice. Presently, two senolytic drugs have undergone human clinical trials. One of them is quercetin, a natural compound found in certain foods. The other is dasatinib, originally developed as an anti-cancer drug. It’s important to note that dasatinib is a prescription-only medication and is associated with some significant side effects.

What is an AMPK Activator?

In recent years, fasting and calorie restriction have gained increased attention for their potential impact on health and lifespan. In animal studies, calorie restriction has demonstrated significant benefits in slowing the aging process and increasing overall healthy lifespan. Researchers have now unraveled the mechanisms by which exercise, calorie restriction, and fasting can enhance health and extend lifespan.

Regular exercise leads to increased energy expenditure, while calorie restriction and fasting reduce energy intake. Together, these activities create an overall effect of reduced energy levels, prompting cells to enter a “survival mode” by activating a signaling pathway known as “AMP-activated protein kinase” (AMPK). Activation of the AMPK pathway sets off a series of advantageous cellular responses, including heightened insulin sensitivity, elevated NAD+ levels, enhanced DNA repair, bolstered immunity, improved stem cell functions, and increased autophagy. Additionally, it helps to reduce inflammation and other detrimental factors. Collectively, these activities contribute to the enhancement of overall health and an extension of lifespan.

While adopting a healthy lifestyle with regular exercise and calorie restriction is effective in activating the AMPK pathway, it’s worth noting that many individuals may struggle to maintain such practices or tolerate reduced food intake. However, scientists have made significant strides in identifying various natural and synthetic compounds that can mimic the effects of exercise and calorie restriction by activating the AMPK pathway. Some of the natural compounds known to have AMPK-activating properties include ellagic acid, urolithin A, resveratrol, quercetin, curcumin, and CoQ10.